20th Biennial Meeting of SFRR International

Online Congress
15–18 March 2021
SFRR-I 2021

Welcome to the 20th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2021) to be held virtually on March 15-18 2021.

The SFRR-I Meeting 2021 is based on the outstanding scientific program of SFRR-I Taiwan 2020. It will provide a valuable update by outstanding scientists with long-lasting expertise in redox Biology and Medicine, promoting new insights into our exciting and developing area.

We appreciate the extensive and excellent work that Prof Ying-Tung Lau and his colleagues undertook to coordinate the 20th Biennial SFRR-I Taiwan Meeting 2020, which was unfortunately canceled due to COVID-19.

The SFRR-I Virtual Meeting 2021 will comprise 5 plenary lectures, 42 symposium lectures, and > 140 communications. Please mark your calendars and join us in March 2021! and Juan Sastre

View Scientific Program Online
Download Scientific Program (PDF)

Monday 15 March 2021

Agenda Monday

15 March 2021
Time CET
Channel 1
Channel 2
08.45 – 09.00
Opening Ceremony
09.00 – 11.00
Symposium  1
Relevance of Oxygen Levels for Stem Cell Redox Biology and Regenerative Medicine

Chairs: & Cellular redox signaling under physiological normoxia and ischemia-reperfusion Transcriptomic and proteomic characterization of human cardiac progenitor cells Maria J. SebastiãoRelevance of oxygen concentration in stem cell culture for regenerative medicine
Do hypoxia mimetic agents provide fidelity in replicating engineered oxygen control measures in human mesenchymal stem cell isolation and culture?

Break 30 min
11.30 – 12.30
Trevor Slater Award Lecture
A redox-centered view of skeletal muscle responses to exercise and aging

Malcolm Jackson
12.30 – 13.30
Oral  Comunications 1
Narrated Communications
Discussion Session 1
Break 1 hour
14.30 – 16.00
Narrated Communications
Discussion Session 2
Narrated Communications
Discussion Session 3
16.00 – 18.00
Symposium 2
Precision Redox and Mitochondrial Quality in Aging

Chair: Chang Chen
Redox-stress response capacity decline and ER reductive stress in agingChang ChenMitochondrial H2O2: new insights from Imaging Mitochondrial Transport and Energy Homeostasis in neuronal degeneration and Regeneration Age and Sex determine the effectiveness of Redox adaptive Homeostasis

Symposium 3
Revising Redox Biology: New Insights from Selenium
Chairs: & New functions of selenoproteins: beyond redox reactivity relative importance of human and mouse selenoproteins

The molecular underpinnings of selenium in ferroptosis The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth factor responses

18.00 – 18.30
SFRR-I Executive Committee Meeting
Agenda Tuesday
16 March 2021
Time CET
Channel 1
Channel 2
09.00 – 11.00
Symposium 4
Role of Redox-active Metals for the Prevention and Treatment of Cancer in the Era of Precision Medicine

Chairs: &Role of Ferroptosis in Carcinogenesis and tumor biology

Targeting cellular signaling to inhibit tumor cell metastasis and growth: The iron and NDRG1 connection

Anticancer platinum and gold compounds with thiol-targeting mechanisms of action
Chun-Nam Lok Nanochelator of iron for improved iron removal efficacy in various disease models

Break 30 min
11.30 – 12.30
Keynote Lecture I
A mitochondrial etiology of complex diseases

Douglas Wallace
12.30 – 13.30
Oral  Comunications 2
Oral  Comunications 3
Break 1 hour
14.30 – 16.00
Narrated Communications
Discussion Session 4
Narrated Communications
Discussion Session 5
16.00 – 18.00
Symposium 5
Redox Regulation of the Epigenetic Landscape

Chair: Epigenetics, the third pillar of nitric oxide signaling

Redox-dependent regulation of chromatin methylation

Regulation of labile Fe(II) and further DNA/histone demethylation by cAMP signaling

Maternal exposure to mitochondrial toxicant results in life-long alterations in the epigenetic landscape of the offspring
Janine Santos

Symposium 6
Nutrition and redox signaling

Chairs: Cesar Fraga &Relevance and bioactivity of flavonoids as regulators of redox signaling
Cesar FragaExercise as an antioxidant supplement to promote healthy aging and delay frailty

Ketogenic diets, nutrient signaling, and mitochondria

Zinc and redox signaling: impact on brain development and function

Agenda Wednesday
17 March 2021
Time CET
Channel 1
Channel 2
09.00 – 11.00

Symposium 7 Redox regulation: Thiols, novel roles, and novel thiols

Chair:Ergothioneine, a thiol/thione antioxidant with therapeutic potentialThe emerging role of coenzyme A and protein CoAlation in redox regulation

The role of Glutathione in bacterial virulence

Human peroxiredoxin 3: oxidizing substrate specificity, glutathionylation, and other oxidative post-translational modifications

Symposium 8
Regulation of Redox Signaling by Nrf2 in Health and Disease

Chair: Young-Joon SurhRole of Nrf2-induced reductive stress in stemness
Young-Joon Surh

The cytoprotective function of NRF2 and its role in sulfur metabolism
Hozumi Motohashi

The NRF2-KEAP1-ARE signal pathway: Regulation and dual role in cancer ROS signaling and Nrf2-mediated adaptive response in type 2 diabetes
Jingbo Pi

Break 30 min
11.30 – 12.30
Keynote Lecture II
Oxidative eustress and oxidative distress
12.30 – 13.30
Oral  Comunications 4
Oral  Comunications 5
13.30 – 14.30
Women in Science Round Table
Lin Mantell, Chang Chen, Carmen Gómez, Ting-Ting Huang, Elizabeth Ledgerwood, Maria Paola Nitti, Patricia Oteiza
14.30 – 16.00
Narrated Communications
Discussion Session 6
Narrated Communications
Discussion Session 7
16.00 – 18.00
Symposium  9
Redox Regulation of Neurovascular and Neurometabolic Coupling in Brain Aging and Disease: A Unifying View

Chairs: & Regulation of neurovascular coupling in the brain mediated by nitric oxide: the redox cycle of ascorbate and nitriteCalcium-dependent Mechanisms of cerebral blood flow regulationRedox signaling in brain endothelial cells adapted to physiological normoxia: consequences for ischemia-reperfusion injury

Glutamate-glutamine cycling and the oxidative metabolism rate in astrocytes

Symposium 10 Senescence and Senolytics in Ageing and Longevity

Chairs: & Sirtuins and mTOR in aging pathways – the role of cell senescenceRepurposing approved drugs and supplements as geroprotectors: Experimental versus epidemiological evidenceMitochondrial Metabolism in T Cell Activation and Aging

Exercise and vascular aging: endothelial redox regulation by Sirt1

NMN Dosage Calculation, methods to determine an optimized NMN dosage with the words first NMN dosage calculator here

18.00 – 18.30
SFRR-I Annual Meeting
Agenda Thursday
18 March 2021
Time CET
Channel 1
Channel 2
09.00 – 11.00
Symposium 11
Oxidative stress and selective mitophagy

Chair:Molecular regulation of mitochondrial autophagy and cellular fate

Oxidative Stress Induced Mitophagy in the Aging Heart

The novel function of mitochondrial outer membrane protein Fis1 in mitochondrial dynamics and quality control

Autophagy of mitochondria and their association with the nucleus in mammals

Break 30 min
11.30 – 12.30
Keynote Lecture III
Reflections of an aging free radical
12.30 – 13.30
Oral  Comunications 6
Oral  Comunications 7
Break 1 hour
14.30 – 16.00
Lester Packer Award Lecture
Discovery of the KEAP1-NRF2 pathway regulating cellular response against oxidative and electrophilic stresses
Masayuki Yamamoto
16.00 – 18.00
Symposium 12
Cellular H2O2 gradients and nanodomains in redox signaling

Chair:Peroxiporins in subcellular redox homeostasis and signaling

Cellular hydrogen peroxide nanodomains

Estimating compartmental hydrogen peroxide steady-state concentrations using experiment and theory

Modeling of cellular hydrogen peroxide landscape

Symposium 13
Detection and quantification of the protein ‘modific-ome’

Chair: &What, where, and how much? Key challenges in protein oxidation

Modifications of cysteine residues in the generation of structurally and functionally diverse protein species

Lipid oxidation products induce specific protein modifications: biological effects and analysis by LC-MS/MS

Oxidative protein modifications of protein therapeutics: targeted proteomic analysis and consequences for stability, efficacy, and immunogenicity

18.00 – 18.30
Awards and Closing Ceremony
Chairs & Speakers
International Scientific Advisory Committee for SFRR-I 2021
Chair of SFRR-I 2021
Juan Sastre
SFRR International
Jose Vina President
Giovanni E. Mann President-Elect
Patricia Oteiza General Secretary
Lin Mantell Treasurer
Shinya Toyokuni Past President
Yuji Naito President
Young-Joon Surh President-Elect
Osamu Handa General Secretary
Hideyuki J. Majima Treasurer
SFRR Australasia
Guy Jameson President
Liz Ledgerwood Past President
Andrew Bulmer President-Elect
Louisa Ashby Secretary
Holly van Remman President
Francisco Laurindo President-Elect
Jianhua Zhang, VP Finance & Advocacy
Kent Lindeman, Executive Director
SFRR Africa
Theesan Bahorun President

SFRR Europe
Daniela Caporrossi President
Michael Davies
Past President
Clare Hawkins General Secretary
Oxygen Club California
Enrique Cadenas Chair, Board of Directors
Registration Fees
150 Euros
Members of SFRR Regional Societies
100 Euros
50 Euros
A certificate of membership/student must be sent to validate a reduced fee registration. Registration fees are Tax/VAT Included.
Sponsorship Registration
Institutional Registration
Abstract Submission
Deadline for abstract submission: 9th December 2020 at 23:00 CET
Submit Abstract
All abstracts should be submitted through this website
  • The title of the abstract should be in bold and not all capitals.
  • The author’s names should not be all capitals and should be a personal name first followed by family names e.g. Pierre Clairmont.
  • The affiliation information should be enough to identify the institute, with city and country – no postal addresses.
  • The body text of the abstract with maximum 300 words.
  • Any keywords etc., should be at the foot of the abstract.
  • References should be avoided, but if essential, then up to maximum of 3.