20th Biennial Meeting of SFRR International

Online Congress
15–18 March 2021
SFRR-I 2021
Welcome to the 20th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2021) to be held virtually on March 15-18 2021.

The SFRR-I Meeting 2021 is based on the outstanding scientific program of SFRR-I Taiwan 2020 and will provide a valuable update by outstanding scientists with long lasting expertise in the field of redox Biology and Medicine promoting new insights into our exciting and developing area.

We appreciate the extensive and excellent work that Prof Ying-Tung Lau and his colleagues undertook to coordinate the 20th Biennial SFRR-I Taiwan Meeting 2020, which was unfortunately cancelled due to COVID-19.

The SFRR-I Virtual Meeting 2021 will comprise 5 plenary lectures, 42 symposium lectures, and > 140 communications. Please mark your calendars and join us in March 2021!

José Viña, Giovanni Mann, and Juan Sastre
View Scientific Program Online
Download Scientific Program (PDF)
Agenda Monday
15 March 2021
Time CET
Channel 1
Channel 2
08.45 – 09.00
Opening Ceremony
09.00 – 11.00
Symposium  1
Relevance of Oxygen Levels for Stem Cell Redox Biology and Regenerative Medicine

Chairs: Giovanni E. Mann & José Viña

Cellular redox signaling under physiological normoxia and ischemia-reperfusion
Giovanni E. Mann

Transcriptomic and proteomic characterization of human cardiac progenitor cells
Maria J. Sebastião

Relevance of oxygen concentration in stem cell culture for regenerative medicine
Consuelo Borras

Do hypoxia mimetic agents’ provide fidelity in replication of engineered oxygen control measures in human mesenchymal stem cell isolation and culture?
Nicholas R. Forsyth
Break 30 min
11.30 – 12.30
Trevor Slater Award Lecture
A redox-centred view of skeletal muscle responses to exercise and ageing

Malcolm Jackson
12.30 – 13.30
Oral  Comunications 1
Narrated Communications
Discussion Session 1
Break 1 hour
14.30 – 16.00
Narrated Communications
Discussion Session 2
Narrated Communications
Discussion Session 3
16.00 – 18.00
Symposium 2
Precision Redox and Mitochondrial Quality in Aging

Chair: Chang Chen

Redox-stress response capacity decline and ER reductive stress in aging
Chang Chen

Mitochondrial H2O2: new insights from imaging
Vsevolod Belousov

Mitochondrial transport and energy homeostasis in neuronal degeneration and regeneration
Zu-Hang Sheng

Age and sex determine the effectiveness of redox adaptive homeostasis
Kelvin J. A. Davies
Symposium 3
Revising Redox Biology: New insights from Selenium
Chairs: Xingen Lei & Yongping Bao

New functions of selenoproteins: beyond redox reactivity
Xingen Lei

Relative importance of human and mouse selenoproteins
Vadim Gladyshev

The molecular underpinnings of selenium in ferroptosis
Marcus Conrad

The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth factor responses
Elias Arnér
18.00 – 18.30
SFRR-I Executive Committee Meeting
Agenda Tuesday
16 March 2021
Time CET
Channel 1
Channel 2
09.00 – 11.00
Symposium 4
Role of Redox-active Metals for the Prevention and Treatment of Cancer in the Era of Precision Medicine

Chairs: Shinya Toyokuni & Des R. Richardson

Role of ferroptosis in carcinogenesis and tumor biology
Shinya Toyokuni

Targeting cellular signalling to inhibit tumour cell metastasis and growth: The iron and NDRG1 connection
Des R. Richardson

Anticancer platinum and gold compounds with thiol-targeting mechanisms of action
Chun-Nam Lok

Nanochelator of iron for improved iron removal efficacy in various disease models
Guangjun Nie
Break 30 min
11.30 – 12.30
Keynote Lecture I
A mitochondrial etiology of complex diseases

Douglas Wallace
12.30 – 13.30
Oral  Comunications 2
Oral  Comunications 3
Break 1 hour
14.30 – 16.00
Narrated Communications
Discussion Session 4
Narrated Communications
Discussion Session 5
16.00 – 18.00
Symposium 5
Redox Regulation of the Epigenetic Landscape

Chair: Frederick Domann

Epigenetics, the third pillar of nitric oxide signalling
Douglas Thomas

Redox-dependent regulation of chromatin methylation
Alison Brewer

Regulation of labile Fe(II) and further DNA/histone demethylation by cAMP signaling
Gaofeng Wang

Maternal exposure to a mitochondrial toxicant results in life-long alterations in the epigenetic landscape of the offspring
Janine Santos
Symposium 6
Nutrition and redox signaling

Chairs: Cesar Fraga & José Viña

Relevance and bioactivity of flavonoids as regulators of redox signalling
Cesar Fraga

Exercise as an antioxidant supplement to promote healthy ageing and delay frailty
José Viña

Ketogenic diets, nutrient signaling and mitochondria
Jon Ramsey

Zinc and redox signaling: impact on brain development and function
Patricia Oteiza
Agenda Wednesday
17 March 2021
Time CET
Channel 1
Channel 2
09.00 – 11.00
Symposium 7
Redox regulation: Thiols, novel roles and novel thiols

Chair: Ivan Gout

Ergothioneine, a thiol/thione antioxidant with therapeutic potential
Barry Halliwell

The emerging role of coenzyme A and protein CoAlation in redox regulation
Ivan Gout

The role of glutathione in bacterial virulence
Yunn Hwen Gan

Human peroxiredoxin 3: oxidizing substrate specificity, glutathionylation and other oxidative post-translational modifications
Madia Trujillo
Symposium 8
Regulation of Redox Signaling by Nrf2 in Health and Disease

Chair: Young-Joon Surh

Role of Nrf2-induced reductive stress in stemness
Young-Joon Surh

Cytoprotective function of NRF2 and its role in sulfur metabolism
Hozumi Motohashi

The NRF2-KEAP1-ARE signal pathway: Regulation and dual role in cancer
Donna D. Zhang

ROS signalling and Nrf2-mediated adaptive response in type 2 diabetes
Jingbo Pi
Break 30 min
11.30 – 12.30
Keynote Lecture II
Oxidative eustress and oxidative distress

Helmut Sies
12.30 – 13.30
Oral  Comunications 4
Oral  Comunications 5
13.30 – 14.30
Women in Science Round Table
Lin Mantell, Chang Chen, Carmen Gómez, Ting-Ting Huang, Elizabeth Ledgerwood, Maria Paola Nitti, Patricia Oteiza
14.30 – 16.00
Narrated Communications
Discussion Session 6
Narrated Communications
Discussion Session 7
16.00 – 18.00
Symposium  9
Redox Regulation of Neurovascular and Neurometabolic Coupling in Brain Aging and Disease: A Unifying View

Chairs: Joao Laranjinha & Enrique Cadenas

Regulation of neurovascular coupling in the brain mediated by nitric oxide: the redox cycle of ascorbate and nitrite
João Laranjinha

Calcium-dependent mechanisms of cerebral blood flow regulation
Martin Lauritzen

Redox signaling in brain endothelial cells adapted to physiological normoxia: consequences for ischemia-reperfusion injury
Giovanni E. Mann

Glutamate-glutamine cycling and the oxidative metabolism rate in astrocytes
João Duarte
Symposium 10
Senescence and Senolytics in Ageing and Longevity

Chairs: Richard Siow & Brian Kennedy

Sirtuins and mTOR in aging pathways – the role of cell senescence
Brian Kennedy

Repurposing approved drugs as geroprotectors: Experimental versus epidemiological evidence
Michael Ristow

Mitochondrial Metabolism in T Cell Activation and Aging
Noga Ron-Harel

Exercise and vascular ageing: endothelial redox regulation by Sirt1
Kun Ling Tsai
18.00 – 18.30
SFRR-I Annual Meeting
Agenda Thursday
18 March 2021
Time CET
Channel 1
Channel 2
09.00 – 11.00
Symposium 11
Oxidative stress and selective mitophagy

Chair: Quan Chen

Molecular regulation of mitochondrial autophagy and cellular fate
Quan Chen

Oxidative Stress Induced Mitophagy in the Aging Heart
Åsa Gustafsson

The novel function of mitochondrial outer membrane protein Fis1 in mitochondrial dynamics and quality control
Yih-Cheng Liou

Autophagy of mitochondria and their association with the nucleus in mammals
Michelangelo Campanella
Break 30 min
11.30 – 12.30
Keynote Lecture III
Reflections of an ageing free radical
Barry Halliwell
12.30 – 13.30
Oral  Comunications 6
Oral  Comunications 7
Break 1 hour
14.30 – 16.00
Lester Packer Award Lecture
Discovery of the KEAP1-NRF2 pathway regulating cellular response against oxidative and electrophilic stresses
Masayuki Yamamoto
16.00 – 18.00
Symposium 12
Cellular H2O2 gradients and nanodomains in redox signaling

Chair: Helmut Sies

Peroxiporins in subcellular redox homeostasis and signaling
Roberto Sitia

Cellular hydrogen peroxide nanodomains
György Hajnoczky

Estimating compartmental hydrogen peroxide steady-state concentrations using experiment and theory
Hadley Sikes

Modeling of cellular hydrogen peroxide landscape
Fernando Antunes
Symposium 13
Detection and quantification of the protein ‘modific-ome’

Chair: Michael Davies & Christian Schöneich

What, where and how much? Key challenges in protein oxidation
Michael Davies

Modifications of cysteine residues in the generation of structurally and functionally diverse protein species
Dolores Perez-Sala

Lipid oxidation products induce specific protein modifications: biological effects and analysis by LC-MS/MS
Corinne Spickett

Oxidative protein modifications of protein therapeutics: targeted proteomic analysis and consequences for stability, efficacy and immunogenicity
Christian Schöneich
18.00 – 18.30
Awards and Closing ceremony
Chairs & Speakers
International Scientific Advisory Committee for SFRR-I 2021
Chair of SFRR-I 2021
Juan Sastre
SFRR International
Jose Vina President
Giovanni E. Mann President-Elect
Patricia Oteiza General Secretary
Lin Mantell Treasurer
Shinya Toyokuni Past President
SFRR Asia
Yuji Naito President
Young-Joon Surh President-Elect
Osamu Handa General Secretary
Hideyuki J. Majima Treasurer
SFRR Australasia
Guy Jameson President
Liz Ledgerwood Past President
Andrew Bulmer President-Elect
Louisa Ashby Secretary
SfRBM
Holly van Remman President
Francisco Laurindo President-Elect
Jianhua Zhang VP Finance & Advocacy
Kent Lindeman Executive Director
SFRR Africa
Theesan Bahorun President

SFRR Europe
Daniela Caporrossi President
Michael Davies
Past President
Clare Hawkins General Secretary
Oxygen Club California
Enrique Cadenas Chair, Board of Directors

Registration Fees
Non members
150 Euros
Members of SFRR Regional Societies
100 Euros
Students/Postdocs
50 Euros
A certificate of membership / student, must be sent to certificates@meetingpharma.com in order to validate a reduced fee registration. Registration fees are Tax/VAT Included
Sponsorship Registration
Sponsorship
Registration Form
Sponsor Area Information (Video)
The demo video is of an existing spanish congress with English voiceover.
Institutional Registration
Institutional
Registration Form
Abstract Submission
Deadline for abstract submission: 9th December 2020 at 23:00 CET
Submit Abstract
(Expired)
All abstracts should be submitted through this website