The Hottest Supplements for Longevity

Longevity and anti-aging research have come a long way, with various supplements and drugs emerging as potential interventions to improve healthspan and lifespan. Among the hottest trends in this field are supplements like:

  • NMN (Nicotinamide Mononucleotide): A precursor to NAD+, crucial for cellular energy production and DNA repair. Activates SIRT1 and SIRT3.
  • NR (Nicotinamide Riboside): Another NAD+ precursor, activating SIRT1 and SIRT3.
  • Spermidine: A naturally occurring polyamine that promotes autophagy.
  • CA-AKG (Calcium Alpha-Ketoglutarate): Reduces inflammation and promotes metabolic health.
  • Trans-Resveratrol: Activates SIRT1, mimicking the effects of calorie restriction.
  • Flavonoid-based supplements:
  • Fisetin: A natural flavonoid with antioxidant and anti-inflammatory properties.
  • Quercetin: Another flavonoid known for its antioxidant effects and potential to activate SIRT1.

Drugs like rapamycin and metformin are also gaining attention for their potential longevity-enhancing properties.

While supplementation has advantages, it has pros and cons to obtaining these benefits from natural foods. Natural foods often contain a complex array of synergistic nutrients, providing a more balanced approach to health and longevity. Furthermore, whole foods may contain additional beneficial compounds not found in isolated supplements. On the other hand, supplementation offers a more targeted and controlled intake of specific compounds that may be difficult to obtain from diet alone.

Similarly, there are pros and cons to consider when comparing supplementation to exercise for promoting longevity. Exercise has been shown to provide various health benefits, such as improved cardiovascular health, increased muscle mass, and reduced inflammation. It also promotes the release of certain hormones, such as irisin, which has been linked to longevity. However, supplementation can provide targeted support for specific biological processes related to aging, which may not be attainable through exercise alone.

Research comparing supplementation and exercise for longevity is limited, but both approaches have unique benefits. While supplementation can target specific aspects of cellular health, exercise offers a more holistic approach, promoting overall well-being. A combination of both strategies would likely yield the best results for promoting healthspan and lifespan.

Rapamycin has been shown to have the most significant longevity benefits among the mentioned interventions in animal studies. However,

it is crucial to note that these findings may not directly translate to humans. One of the primary concerns regarding rapamycin is its potential to suppress the immune system, which could increase vulnerability to infections and other health complications. Moreover, the long-term safety of rapamycin use in humans remains uncertain. More research is needed to determine the optimal dosage and administration to balance its potential benefits and risks.

In conclusion, the field of longevity research is rapidly evolving, with various supplements and drugs showing promise in promoting healthspan and lifespan. While supplementation can provide targeted support for specific aging-related processes, natural foods, and exercise also play vital roles in maintaining overall health and well-being. As more research emerges, it is essential to approach these interventions cautiously and consider potential risks and benefits before incorporating them into a longevity-promoting lifestyle.

A Closer Look at the Health Benefits of NMN for Longevity and Healthspan

NMN, or Nicotinamide Mononucleotide, is a natural compound with signifcant attention in longevity and anti-aging. While no specific scientist is accredited as the person who discovered NMN, the earliest research mentioning NMN dates back to 1963 to three researchers, Pierre Chambon, Jean-Daniel Weill, and Pierre Mandel (r). Their work focused on the role of NMN in the biosynthesis of NAD+ and its importance in cellular metabolism. NMN is crucial in producing NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for various cellular processes and energy metabolism.

NAD+ is a vital coenzyme in many biological processes, including DNA repair, cellular metabolism, and energy production. NMN serves as a precursor to NAD+, which helps create more NAD+ in the body. As we age, NAD+ levels decline, leading to a decrease in cellular energy and an increase in age-related health issues.

Research and studies have shown that NMN supplementation can provide numerous health benefits. These include:

– Improved cellular energy production

– Enhanced DNA repair and cellular stress resistance

– Promoting healthy aging and longevity

– Supporting cognitive function and neuroprotection

– Improved metabolic health and insulin sensitivity

– Potential Longevity and Healthspan Benefits 

Some specific studies on NMN in humans are:

– A study published in 2019 in the journal Endocrine Reviews showed that NMN supplementation improved glucose metabolism and insulin sensitivity in older adults.

– A 2020 study published in the journal Nature Metabolism demonstrated that NMN supplementation helped maintain mitochondrial function in aged mice, leading to improved physical activity and a longer lifespan.

– A 2021 clinical trial conducted at the University of California, San Francisco, investigating the effects of NMN supplementation on cognitive function, exercise capacity, and metabolic health in older adults (results are pending).

Several books and publications reference NMN and its role in longevity and health:

1. “Lifespan: Why We Ageā€”and Why We Don’t Have To” by David A. Sinclair, Ph.D., and Matthew D. LaPlante: This book explores the science behind aging and discusses various interventions, including the use of NMN, to slow down the aging process and improve overall health.

2. “The NAD+ Supplement Review: The Science Behind NAD+ Boosters” by Dr. Brad Stanfield: This book provides a comprehensive overview of NAD+ boosters, including NMN, and their potential benefits in promoting health and longevity.

3. “The Longevity Paradox: How to Die Young at a Ripe Old Age” by Dr. Steven R. Gundry: This book discusses various strategies for healthy aging, including the role of NAD+ and its precursors, such as NMN, in maintaining optimal health as we age

NAD+ levels decline with age, and boosting them through dietary means can be challenging. Foods rich in NAD+ precursors, such as dairy, fish, and whole grains, may provide some benefits. However, NMN supplementation has been proven more effective in increasing NAD+ levels and promoting overall health and longevity.

If you are after a quick, easy explanation of NMN for longevity, I found the below Youtube video, which gives the best base level of understanding for someone new to the longevity scene.

NMN has distinct advantages when comparing NMN to another NAD+ precursor, NR (Nicotinamide Riboside). NMN is structurally closer to NAD+, meaning it can be more efficiently converted into NAD+ in the body. NR, on the other hand, must first be converted into NMN before being utilized as NAD+. This extra step can result in a less efficient conversion process, making NMN supplementation more effective for boosting NAD+ levels.