15–18 March 2021
Welcome to the 20th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2021) to be held virtually on March 15-18 2021.
The SFRR-I Meeting 2021 is based on the outstanding scientific program of SFRR-I Taiwan 2020. It will provide a valuable update by outstanding scientists with long-lasting expertise in redox Biology and Medicine, promoting new insights into our exciting and developing area.
We appreciate the extensive and excellent work that Prof Ying-Tung Lau and his colleagues undertook to coordinate the 20th Biennial SFRR-I Taiwan Meeting 2020, which was unfortunately canceled due to COVID-19.
The SFRR-I Virtual Meeting 2021 will comprise 5 plenary lectures, 42 symposium lectures, and > 140 communications. Please mark your calendars and join us in March 2021! and Juan Sastre
Monday 15 March 2021
Relevance of Oxygen Levels for Stem Cell Redox Biology and Regenerative Medicine
Chairs: & Cellular redox signaling under physiological normoxia and ischemia-reperfusion Transcriptomic and proteomic characterization of human cardiac progenitor cells Maria J. SebastiãoRelevance of oxygen concentration in stem cell culture for regenerative medicine
Do hypoxia mimetic agents provide fidelity in replicating engineered oxygen control measures in human mesenchymal stem cell isolation and culture?
A redox-centered view of skeletal muscle responses to exercise and aging
Malcolm Jackson
Discussion Session 1
Discussion Session 2
Discussion Session 3
Precision Redox and Mitochondrial Quality in Aging
Chair: Chang Chen
Revising Redox Biology: New Insights from Selenium
Chairs: & New functions of selenoproteins: beyond redox reactivity relative importance of human and mouse selenoproteins
The molecular underpinnings of selenium in ferroptosis The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth factor responses
16 March 2021
Role of Redox-active Metals for the Prevention and Treatment of Cancer in the Era of Precision Medicine
Chairs: &Role of Ferroptosis in Carcinogenesis and tumor biology
Targeting cellular signaling to inhibit tumor cell metastasis and growth: The iron and NDRG1 connection
Anticancer platinum and gold compounds with thiol-targeting mechanisms of action
Chun-Nam Lok Nanochelator of iron for improved iron removal efficacy in various disease models
A mitochondrial etiology of complex diseases
Douglas Wallace
Discussion Session 4
Discussion Session 5
Redox Regulation of the Epigenetic Landscape
Chair: Epigenetics, the third pillar of nitric oxide signaling
Redox-dependent regulation of chromatin methylation
Regulation of labile Fe(II) and further DNA/histone demethylation by cAMP signaling
Maternal exposure to mitochondrial toxicant results in life-long alterations in the epigenetic landscape of the offspring
Janine Santos
Nutrition and redox signaling
Chairs: Cesar Fraga &Relevance and bioactivity of flavonoids as regulators of redox signaling
Cesar FragaExercise as an antioxidant supplement to promote healthy aging and delay frailty
Ketogenic diets, nutrient signaling, and mitochondria
Zinc and redox signaling: impact on brain development and function
17 March 2021
Symposium 7 Redox regulation: Thiols, novel roles, and novel thiols
The role of Glutathione in bacterial virulence
Human peroxiredoxin 3: oxidizing substrate specificity, glutathionylation, and other oxidative post-translational modifications
Regulation of Redox Signaling by Nrf2 in Health and Disease
Chair: Young-Joon SurhRole of Nrf2-induced reductive stress in stemness
Young-Joon Surh
The cytoprotective function of NRF2 and its role in sulfur metabolism
Hozumi Motohashi
The NRF2-KEAP1-ARE signal pathway: Regulation and dual role in cancer ROS signaling and Nrf2-mediated adaptive response in type 2 diabetes
Jingbo Pi
Oxidative eustress and oxidative distress
Lin Mantell, Chang Chen, Carmen Gómez, Ting-Ting Huang, Elizabeth Ledgerwood, Maria Paola Nitti, Patricia Oteiza
Discussion Session 6
Discussion Session 7
Redox Regulation of Neurovascular and Neurometabolic Coupling in Brain Aging and Disease: A Unifying View
Chairs: & Regulation of neurovascular coupling in the brain mediated by nitric oxide: the redox cycle of ascorbate and nitriteCalcium-dependent Mechanisms of cerebral blood flow regulationRedox signaling in brain endothelial cells adapted to physiological normoxia: consequences for ischemia-reperfusion injury
Glutamate-glutamine cycling and the oxidative metabolism rate in astrocytes
Symposium 10 Senescence and Senolytics in Ageing and Longevity
Exercise and vascular aging: endothelial redox regulation by Sirt1
NMN Dosage Calculation, methods to determine an optimized NMN dosage with the words first NMN dosage calculator here
18 March 2021
Oxidative stress and selective mitophagy
Chair:Molecular regulation of mitochondrial autophagy and cellular fate
Oxidative Stress Induced Mitophagy in the Aging Heart
The novel function of mitochondrial outer membrane protein Fis1 in mitochondrial dynamics and quality control
Autophagy of mitochondria and their association with the nucleus in mammals
Reflections of an aging free radical
Discovery of the KEAP1-NRF2 pathway regulating cellular response against oxidative and electrophilic stresses
Masayuki Yamamoto
Cellular H2O2 gradients and nanodomains in redox signaling
Chair:Peroxiporins in subcellular redox homeostasis and signaling
Cellular hydrogen peroxide nanodomains
Estimating compartmental hydrogen peroxide steady-state concentrations using experiment and theory
Modeling of cellular hydrogen peroxide landscape
Detection and quantification of the protein ‘modific-ome’
Chair: &What, where, and how much? Key challenges in protein oxidation
Modifications of cysteine residues in the generation of structurally and functionally diverse protein species
Lipid oxidation products induce specific protein modifications: biological effects and analysis by LC-MS/MS
Oxidative protein modifications of protein therapeutics: targeted proteomic analysis and consequences for stability, efficacy, and immunogenicity
Giovanni E. Mann President-Elect
Patricia Oteiza General Secretary
Lin Mantell Treasurer
Shinya Toyokuni Past President
Young-Joon Surh President-Elect
Osamu Handa General Secretary
Hideyuki J. Majima Treasurer
Liz Ledgerwood Past President
Andrew Bulmer President-Elect
Louisa Ashby Secretary
Francisco Laurindo President-Elect
Jianhua Zhang, VP Finance & Advocacy
Kent Lindeman, Executive Director
Michael Davies Past President
Clare Hawkins General Secretary
(Expired)
- The title of the abstract should be in bold and not all capitals.
- The author’s names should not be all capitals and should be a personal name first followed by family names e.g. Pierre Clairmont.
- The affiliation information should be enough to identify the institute, with city and country – no postal addresses.
- The body text of the abstract with maximum 300 words.
- Any keywords etc., should be at the foot of the abstract.
- References should be avoided, but if essential, then up to maximum of 3.